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The mechanism of action of synthetic Culexcorticotropin-releasing factor (CRF)-like diuretic peptide (CCRF-DP) was investigated in isolated, perfused Malpighian tubules of the yellow fever mosquito, Aedes aegypti. Low concentrations of CCRF-DP (10 −10  and 10 −9  M) caused depolarizing oscillations of the lumen-positive transepithelial voltage ( V  t ) in Malpighian tubules, whereas high concentrations (10 −8  and 10 −7  M) first depolarized and then transiently hyperpolarized V  t ; CCRF-DP always lowered transepithelial resistance ( R  t ), regardless of voltage depolarization or hyperpolarization. The short-circuit current ( I  sc ), an electrical estimate of active transepithelial transport of Na and K, remained unchanged at low concentrations of CCRF-DP, but I  sc  more than doubled at high concentrations. These effects of CCRF-DP suggest dose-dependent sites of action: low concentrations of CCRF-DP affect the paracellular pathway, and high concentrations affect both paracellular and transcellular pathways.

Dose-dependent effects of CRF-like diuretic peptide on transcellular and paracellular transport pathways