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Impairment in the ability of the skin to properly store Na +  nonosmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our laboratory has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na +  handling. Furthermore, it is well established that loss of endothelin type B receptor (ET B ) receptor function impairs Na +  excretion by the kidney. Thus we hypothesized that rats lacking functional ET B  receptors (ET B -def) will have a reduced capacity of the skin to store Na +  during chronic high-salt (HS) intake. We observed that ET B -def rats exhibited salt-sensitive hypertension with an approximate doubling in the diurnal amplitude of mean arterial pressure compared with genetic control rats on a HS diet. Two weeks of HS diet significantly increased skin Na +  content relative to water; however, there was no significant difference between control and ET B -def rats. Interestingly, HS intake led to a 19% increase in skin Na +  and 16% increase in water content (relative to dry wt.) during the active phase (zeitgeber time 16) versus inactive phase (zeitgeber time 4, P &lt; 0.05) in ET B -def rats. There was no significant circadian variation in total skin Na +  or water content of control rats fed normal or HS. These data indicate that ET B  receptors have little influence on the ability to store Na +  nonosmotically in the skin during long-term HS intake but, rather, appear to regulate diurnal rhythms in skin Na +  content and circadian blood pressure rhythms associated with a HS diet.

american journal of physiology. regulatory, integrative and comparative physiology/american journal of physiology. regulatory, integrative, and comparative physiology

Diurnal pattern in skin Na+ and water content is associated with salt-sensitive hypertension in ETB receptor-deficient rats

Diurnal pattern in skin Na⁺ and water content is associated with salt-sensitive hypertension in ET_B receptor-deficient rats