Open AccessSeeing cilia: imaging modalities for ciliary motion and clinical connections
Author(s) -
J.E. Peabody Lever,
RenJay Shei,
B Bermingham,
Scott E. Phillips,
Brett Turner,
Steven M. Rowe,
George M. Solomon
Publication year - 2018
Publication title -
american journal of physiology-lung cellular and molecular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.892
H-Index - 163
eISSN - 1522-1504
pISSN - 1040-0605
DOI - 10.1152/ajplung.00556.2017
Subject(s) - primary ciliary dyskinesia , cilium , mucociliary clearance , ciliopathies , modalities , cystic fibrosis , medicine , optical coherence tomography , disease , pathology , bronchiectasis , neuroscience , radiology , biology , lung , microbiology and biotechnology , sociology , gene , phenotype , biochemistry , social science
The respiratory tract is lined with multiciliated epithelial cells that function to move mucus and trapped particles via the mucociliary transport apparatus. Genetic and acquired ciliopathies result in diminished mucociliary clearance, contributing to disease pathogenesis. Recent innovations in imaging technology have advanced our understanding of ciliary motion in health and disease states. Application of imaging modalities including transmission electron microscopy, high-speed video microscopy, and micron-optical coherence tomography could improve diagnostics and be applied for precision medicine. In this review, we provide an overview of ciliary motion, imaging modalities, and ciliopathic diseases of the respiratory system including primary ciliary dyskinesia, cystic fibrosis, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.
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