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Although the cerebrospinal fluid system has been the subject of extensive study, most workers have concerned themselves mainly with the mechanics of the formation and reabsorption of this fluid, relatively little attention having been paid to the relationships existing between the cerebrospinal fluid and the tissue fluid of the brain and spinal cord. The probability of free communication between the subarachnoid space and the timue spaces of the nervous system has been demonstrated by Mott (1910), Weed (1914), and others. If such communication does exist, it is reasonable to assume that any change in the composition of the cerebrospinal fluid will be reflected by a similar change in the composition of the intirstitial fluids, and thus possibly by modified activity of the neurones bathed by the latter. Several workers have reporkd spontaneous neuromuscular activity following the intrathecal administration of various solutions. Collip (1920) observed tetanoid behavior in dogs following the introduction of small volumes of NaHCOa, hypertonic NaCl and KCl, and NasHPOJ into the lumbar subarachnoid space. CaCll antagonized this motor activity, and it was concluded that the tetany was due to a disturbance in the concentrations of the various cations, especially of calcium. Huggins and Hastings (1933) observed that the injection of sodium citrate into the cisterna magna of the dog produced motor excitation which was antagonized by calcium chloride. Calcium citrate provoked no motor response. Mullin, Hastings, and Lees (1938) produced tetany by the cisternal injection of salt solutions which were ionically balanced except for the absence of calcium, Similar results were obtained with the injection of sodium citrate. Bathing the lower spinal cord with the calcium-free solution ~8s ineffective, although here too citrate produced spontaneous neuromuscular activity.

THE EFFECT OF CHANGES IN THE CALCIUM CONTENT OF THE CEREBROSPINAL FLUID ON SPINAL REFLEX ACTIVITY IN THE DOG