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The numerous reports in the literature showing the marked efficacy of fats, egg-yolk and meat protein in emptying the gall bladder convinced us that the effect of %ecretin” on the evacuation and motor activity of the gall bladder should be studied, since it is well known that these substances stimulate the pancrew, and that “secretin” (very impure solutions) promotes the formation of bile. With this objective in mind, we have performed several series of experiments, the results of which prove, we believe, that a hormone mechanism is concerned in gall-bladder contraction and evacuation. For some time Ivy, Kloster and Lueth (1927) have been working on the purification of 3ecretin” for the purpose of perfecting a pancreatic function test for man. In our work we have used the preparations prepared for us by them. The solutions furnished us were “highly purified,” were vasodilatin-free, and have had no objective deleterious action when injected intravenously in succi but they do not state’ the method by which the “Becretin” used by them was prepared. Brugsch and Horsters (1926) placed a coridom balloon in the gall bladder of dogs and found that 10 cc. of a preparation of Dale and Laidlaw (1912-13) “secretin” caused a confraction and rhythmic changes of the gall bladder, and “hypo-

A HORMONE MECHANISM FOR GALL-BLADDER CONTRACTION AND EVACUATION