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The present study sought to compare the temporal relation between maximal coronary flow (peak hyperemia) and minimal coronary-to-aortic pressure ratio (P d /P a ) for intracoronary (IC) and intravenous (IV) adenosine administration. Peak hyperemia is assumed to coincide with the minimal P d /P a value. However, this has not been confirmed for systemic hemodynamic variations during IV adenosine infusion. Hemodynamic responses to IV and IC adenosine administration were obtained in 12 patients (14 lesions) using combined IC pressure and flow velocity measurements. A fluid dynamic model was used to predict the change in P d /P a for different stenosis severities and varying P a Hemodynamic variability during IV adenosine hyperemia was greater than during IC adenosine, as assessed by the coefficient of variation. During IV adenosine, flow velocity peaked 28 ± 4 (SE) s after the onset of hyperemia, while P d /P a reached a minimum (0.82 ± 0.01) 22 ± 7 s later ( P &lt; 0.05), when P a had declined by 6.1% and hyperemic velocity by 4.5% ( P &lt; 0.01). Model outcomes corroborated the role of variable P a in this dissociation. In contrast, maximal flow and minimal P d /P a coincided for IC adenosine, with IV-equivalent peak velocities and a higher P d /P a ratio (0.86 ± 0.01, P &lt; 0.01). Hemodynamic variability during continuous IV adenosine infusion can lead to temporal dissociation of minimal P d /P a and peak hyperemia, in contrast to IC adenosine injection, where maximal velocity and minimal P d /P a coincide. Despite this variability, stenosis hemodynamics remained stable with both ways of adenosine administration. Our findings suggest advantages of IC over IV adenosine to identify maximal hyperemia from pressure-only measurements. NEW &amp; NOTEWORTHY Systemic hemodynamic variability during intravenous adenosine infusion produces substantial temporal dissociation between peak hyperemia appraised by coronary flow velocity and the minimal distal-to-aortic pressure ratio commonly used to determine functional stenosis severity. This dissociation was absent for intracoronary adenosine administration and tended to be mitigated in patients receiving Ca 2+ antagonists.

Temporal dissociation between the minimal distal-to-aortic pressure ratio and peak hyperemia during intravenous adenosine infusion