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We tested the hypothesis that dietary nitrate (NO 3  - )-rich beetroot juice (BR) supplementation could partially offset deteriorations in O 2 transport and utilization and exercise tolerance after blood donation. Twenty-two healthy volunteers performed moderate-intensity and ramp incremental cycle exercise tests prior to and following withdrawal of ∼450 ml of whole blood. Before donation, all subjects consumed seven 70-ml shots of NO 3  - -depleted BR [placebo (PL)] in the 48 h preceding the exercise tests. During the 48 h after blood donation, subjects consumed seven shots of BR (each containing 6.2 mmol of NO 3  - , n = 11) or PL (n = 11) before repeating the exercise tests. Hemoglobin concentration and hematocrit were reduced by ∼8-9% following blood donation (P &lt; 0.05), with no difference between the BR and PL groups. Steady-state O 2 uptake during moderate-intensity exercise was ∼4% lower after than before donation in the BR group (P &lt; 0.05) but was unchanged in the PL group. The ramp test peak power decreased from predonation (341 ± 70 and 331 ± 68 W in PL and BR, respectively) to postdonation (324 ± 69 and 322 ± 66 W in PL and BR, respectively) in both groups (P &lt; 0.05). However, the decrement in performance was significantly less in the BR than PL group (2.7% vs. 5.0%, P &lt; 0.05). NO 3  - supplementation reduced the O 2 cost of moderate-intensity exercise and attenuated the decline in ramp incremental exercise performance following blood donation. These results have implications for improving functional capacity following blood loss.

Dietary nitrate supplementation attenuates the reduction in exercise tolerance following blood donation