English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Voltage-gated sodium channel α-subunits have been shown to be key mediators of the pathophysiology of pain. The present review considers the role of sodium channel auxiliary β-subunits in channel modulation, channel protein expression levels, and interactions with extracellular matrix and cytoskeletal signaling molecules. Although β-subunits have not yet been directly implicated in pain mechanisms, their intimate association with and ability to regulate α-subunits predicts that they may be a viable target for therapeutic intervention in the future. It is proposed that multifunctional sodium channel β-subunits provide a critical link between extracellular and intracellular signaling molecules and thus have the ability to fine tune channel activity and electrical excitability.

I. Cellular and molecular biology of sodium channel β-subunits: therapeutic implications for pain?