Open AccessParallel intermediate conductance K+ and Cl− channel activity mediates electroneutral K+ exit across basolateral membranes in rat distal colon
Author(s) -
Shabina Rehman,
Karthikeyan Narayanan,
Andrew J. Nickerson,
Steven Coon,
Kazi Mirajul Hoque,
Geoffrey I. Sandle,
Vazhaikkurichi M. Rajendran
Publication year - 2020
Publication title -
american journal of physiology-gastrointestinal and liver physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.644
H-Index - 169
eISSN - 1522-1547
pISSN - 0193-1857
DOI - 10.1152/ajpgi.00011.2020
Subject(s) - cotransporter , conductance , chemistry , membrane , symporter , biophysics , transporter , biochemistry , sodium , biology , physics , gene , condensed matter physics , organic chemistry
This study demonstrates that during active electroneutral K + absorption in rat distal colon, K + exit across the basolateral membrane mainly reflects intermediate conductance K + channels operating in conjunction with chloride channel 2, with a smaller but significant contribution from K + -Cl − cotransporter-1 activity.
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