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Overall proteolysis and the activity of skeletal muscle proteolytic systems were investigated in rats 1, 2, or 4 days after adrenodemedullation. Adrenodemedullation reduced plasma epinephrine by 95% and norepinephrine by 35% but did not affect muscle norepinephrine content. In soleus and extensor digitorum longus (EDL) muscles, rates of overall proteolysis increased by 15–20% by 2 days after surgery but returned to normal levels after 4 days. The rise in rates of protein degradation was accompanied by an increased activity of Ca 2+ -dependent proteolysis in both muscles, with no significant change in the activity of lysosomal and ATP-dependent proteolytic systems. In vitro rates of Ca 2+ -dependent proteolysis in soleus and EDL from normal rats decreased by ∼35% in the presence of either 10 −5  M clenbuterol, a β 2 -adrenergic agonist, or epinephrine or norepinephrine. In the presence of dibutyryl cAMP, proteolysis was reduced by 62% in soleus and 34% in EDL. The data suggest that catecholamines secreted by the adrenal medulla exert an inhibitory control of Ca 2+ -dependent proteolysis in rat skeletal muscle, mediated by β 2 -adrenoceptors, with the participation of a cAMP-dependent pathway.

Catecholamines inhibit Ca2+-dependent proteolysis in rat skeletal muscle through β2-adrenoceptors and cAMP

Catecholamines inhibit Ca²⁺-dependent proteolysis in rat skeletal muscle through β₂-adrenoceptors and cAMP