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the hormonal activation of cAMP production in pancreatic β-cells is accompanied by an increase of cytosolic [cAMP] that can be measured in real time through the use of a cAMP sensor (Epac1-camps) that exhibits a decrease of fluorescence resonance energy transfer (FRET) when it binds to cAMP ([9][1

american journal of physiology. cell physiology

Synchronizing Ca2+and cAMP oscillations in pancreatic β-cells: a role for glucose metabolism and GLP-1 receptors?Focus on “Regulation of cAMP dynamics by Ca2+and G protein-coupled receptors in the pancreatic β-cell: a computational approach”