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Recent advances in fabrication techniques allows one to create regular nanofluidic pores and channels down to 15~20nm in critical dimension, with excellent uniformity and size control. This creates unique opportunities for molecular sieving, since now one can manufacture even a ‘membrane’ with regular pore shape, and the sizes which were only possible with random nanoporous materials such as gel and polymer monolith. Such a massively parallel nanofluidic membrane would have many applications in molecular separation, photonics, and possibly any membrane applications.

Nanofluidic Channels as Advanced Molecular Sieves: Continuous-Flow DNA and Protein Separation