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Wearable electrochemical sensors have the potential to overcome the problem of infrequent clinical visits that leads to transient events of potential diagnostic importance being unduly overlooked. The promise of real-time, personalized health care has driven multidisciplinary work on fabricating various forms of wearable sensors. Although remarkable advances in device form factor and integrated circuit design have been achieved, notable hurdles, such as shelf life, reuseability, flex and sweat resistance, and longitudinal performance, remain unaddressed. This perspective seeks to summarize major advances in current wearable electrochemical sensors and to highlight the most pressing challenges that will benefit from collective research endeavors.

Perspective—Challenges in Developing Wearable Electrochemical Sensors for Longitudinal Health Monitoring