Open AccessTopPIC Gateway: A Web Gateway for Top-Down Mass Spectrometry Data Interpretation
Author(s) -
In Kwon Choi,
Eroma Abeysinghe,
Eric Coulter,
Suresh Marru,
Marlon Pierce,
Xiaowen Liu
Publication year - 2020
Publication title -
practice and experience in advanced research computing
Language(s) - English
Resource type - Conference proceedings
ISBN - 978-1-4503-6689-2
DOI - 10.1145/3311790.3400853
Subject(s) - gateway (web page) , computer science , suite , cloud computing , software , resource (disambiguation) , software suite , world wide web , operating system , computer network , archaeology , history
Top-down mass spectrometry-based proteomics has become the method of choice for identifying and quantifying intact proteoforms in biological samples. We present a web-based gateway for TopPIC suite, a widely used software suite consisting of four software tools for top-down mass spectrometry data interpretation: TopFD, TopPIC, TopMG, and TopDiff. The gateway enables the community to use heterogeneous collection of computing resources that includes high performance computing clusters at Indiana University and virtual clusters on XSEDE’s Jetstream Cloud resource for top-down mass spectral data analysis using TopPIC suite. The gateway will be a useful resource for proteomics researchers and students who have limited access to high-performance computing resources or who are not familiar with interacting with server-side supercomputers.
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