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High-resolution blood flow simulations have potential for developing betterunderstanding biophysical phenomena at the microscale, such as vasodilation,vasoconstriction and overall vascular resistance. To this end, we present ascalable platform for the simulation of red blood cell (RBC) flows throughcomplex capillaries by modeling the physical system as a viscous fluid withimmersed deformable particles. We describe a parallel boundary integralequation solver for general elliptic partial differential equations, which weapply to Stokes flow through blood vessels. We also detail a parallel collisionavoiding algorithm to ensure RBCs and the blood vessel remain contact-free. Wehave scaled our code on Stampede2 at the Texas Advanced Computing Center up to34,816 cores. Our largest simulation enforces a contact-free state between fourbillion surface elements and solves for three billion degrees of freedom on onemillion RBCs and a blood vessel composed from two million patches.

Scalable Simulation of Realistic Volume Fraction Red Blood Cell Flows through Vascular Networks