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This study indicates that in E6 grand unified theories (GUTs), once ahierarchical structure of up-quark-type Yukawa couplings is given as a basicstructure of flavor, larger lepton mixings than the quark mixings and milderdown-quark-type (and charged-lepton-type) mass hierarchies than up-quark-typemass hierarchy can generically be obtained under a few natural assumptions. Thebasic flavor structure is compatible with non-Abelian horizontal symmetry,which can solve the SUSY flavor problem. It is shown that in solving the SUSYflavor problem, the E6 structure, which realizes bi-large neutrino mixings,also solves a problem that results from the large neutrino mixing angles.Comment: 8 pages, RevTeX, In Ver.2, refs. and minor correction

E6 Unification, Large Neutrino Mixings and SUSY Flavor Problem