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A scenario of SO(10) grand unified theory (GUT) proposed by one of theauthors is extended to E_6 unification. This gives realistic quark and leptonmass matrices. In neutrino sector, the model reproduces large mixing angle(LMA) MSW solution as well as large mixing angle for atmospheric neutrinoanomaly. In this model, right-handed down quark and left-handed lepton of thefirst and second generation belong to a single multiplet 27. This causesnatural suppression of flavor changing neutral current(FCNC).Comment: 23 pages, V2:published versio

E6 Unification with Bi-Large Neutrino Mixing