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We study global fluctuations of the guanine and cytosine base content (GC%)in mouse genomic DNA using spectral analyses. Power spectra S(f) of GC%fluctuations in all nineteen autosomal and two sex chromosomes are observed tohave the universal functional form S(f) \sim 1/f^alpha (alpha \approx 1) overseveral orders of magnitude in the frequency range 10^-7< f < 10^-5 cycle/base,corresponding to long-ranging GC% correlations at distances between 100 kb and10 Mb. S(f) for higher frequencies (f > 10^-5 cycle/base) shows a flattenedpower-law function with alpha < 1 across all twenty-one chromosomes. Thesubstitution of about 38% interspersed repeats does not affect the functionalform of S(f), indicating that these are not predominantly responsible for thelong-ranged multi-scale GC% fluctuations in mammalian genomes. Severalbiological implications of the large-scale GC% fluctuation are discussed,including neutral evolutionary history by DNA duplication, chromosomal bands,spatial distribution of transcription units (genes), replication timing, andrecombination hot spots.Comment: 15 pages (figures included), 2 figure

SPECTRAL ANALYSIS OF GUANINE AND CYTOSINE FLUCTUATIONS OF MOUSE GENOMIC DNA