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Based on our experience in kinetic modeling of coupled multiple metabolicpathways we propose a generic rate equation for the dynamical modeling ofmetabolic kinetics. Its symmetric form makes the kinetic parameters (orfunctions) easy to relate to values in database and to use in computation. Inaddition, such form is workable to arbitrary number of substrates and productswith different stoichiometry. We explicitly show how to obtain such rateequation exactly for various binding mechanisms. Hence the proposed rateequation is formally rigorous. Various features of such a generic rate equationare discussed. For irreversible reactions, the product inhibition whichdirectly arise from enzymatic reaction is eliminated in a natural way. We alsodiscuss how to include the effects of modifiers and cooperativity.

A Generic Rate Equation for modeling Enzymatic Reactions under Living Conditions