English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Oscillatory behaviour in force-generating systems is a pervasive phenomenonin cell biology. In this work, we investigate how oscillations in theactomyosin cytoskeleton drive cell shape changes during the process of DorsalClosure, a morphogenetic event in Drosophila embryo development wherebyepidermal continuity is generated through the pulsatile apical area reductionof cells constituting the amnioserosa (AS) tissue. We present a theoreticalmodel of AS cell dynamics by which the oscillatory behaviour arises due to acoupling between active Myosin-driven forces, actin turnover and celldeformation. Oscillations in our model are cell-autonomous and are modulated byneighbour coupling, and our model accurately reproduces the oscillatorydynamics of AS cells and their amplitude and frequency evolution. A keyprediction arising from our model is that the rate of actin turnover and Myosincontractile force must increase during DC in order to reproduce the decrease inamplitude and period of cell area oscillations observed in vivo. Thisprediction opens up new ways to think about the molecular underpinnings of AScell oscillations and their link to net tissue contraction and suggests theform of future experimental measurements.

Cytoskeletal turnover and Myosin contractility drive cell autonomous oscillations in a model of Drosophila Dorsal Closure