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Noisy saltatory spike propagation along myelinated axons is studied within astochastic Hodgkin-Huxley model. The intrinsic noise (whose strength is inverseproportional to the nodal membrane size) arising from fluctuations of thenumber of open ion channels influences the dynamics of the membrane potentialin a node of Ranvier where the sodium ion channels are predominantly localized.The nodes of Ranvier are linearly coupled. As the measure for the signalpropagation reliability we focus on the ratio between the number of initiatedspikes and the transmitted spikes. This work supplements our earlier study [A.Ochab-Marcinek, G. Schmid, I. Goychuk and P. H\"anggi, Phys. Rev E 79, 011904(2009)] towards stronger channel noise intensity and supra-threshold coupling.For strong supra-threshold coupling the transmission reliability decreases withincreasing channel noise level until the causal relationship is completely lostand a breakdown of the spike propagation due to the intrinsic noise isobserved.

Noisy saltatory spike propagation: The breakdown of signal transmission due to channel noise