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The measurements of the ratios $R_{K^{(*)}}$ along with $R_{D^{(*)}}$ hinttowards lepton flavor non universality which is in disagreement with thestandard model. In this work, we reanalyze the four new physics models, whichare widely studied in the literature as a candidates for the simultaneousexplanations of these measurements. These are, standard model like vector boson(VB), $SU(2)_L$-singlet vector leptoquark ($U_1$), $SU(2)_L$-triplet scalarleptoquark ($S_3$) and $SU(2)_L$ triplet vector leptoquark ($U_3$) models. Weassume a coupling only to the third generation in the weak basis, so that the$b \to s \mu^+ \mu^-$ transition is generated only via mixing effects.Preforming a global fit to all relevant data, we show that the vector bosonmodel violates the current upper bound on ${Br}(\tau \to 3\mu)$ and hence isinconsistent with the present data. Further, we show that within thisframework, the $U_1$ leptoquark model cannot simultaneously accommodate$R_{K^{(*)}}$ and $R_{D^{(*)}}$ measurements. We emphasize that this conclusionis independent of the additional constraints coming from renormaliztion grouprunning effects and high-$p_T$ searches. In addition, we show that the $S_3$and $U_3$ models are highly disfavored by the constraints coming from $b\to s\nu \bar \nu$ data. Finally, we find a that hypothesis of two LQ particles isalso challenged by $b\to s \bar \nu \nu$ data.

Lepton flavor non-universality in the B-sector: a global analyses of various new physics models