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In this paper, we propose a viable approach to realise two texture-zeros inthe scotogenic model with flavor dependent $U(1)_{B-2L_\alpha-L_\beta}$ gaugesymmetry. These models are extended by two right-handed singlets $N_{Ri}$ andtwo inert scalar doublets $\eta_{i}$, which are odd under the dark $Z_2$symmetry. Among all the six constructed textures, texture $A_1$ and $A_2$ arethe only two allowed by current experimental limits. Then choosing texture$A_1$ derived from $U(1)_{B-2L_e-L_\tau}$, we perform a detail analysis on thecorresponding phenomenology such as predictions of neutrino mixing parameters,lepton flavor violation, dark matter and collider signatures. One distinctnature of such model is that the structure of Yukawa coupling$\bar{L}\tilde{\eta}N_R$ is fixed by neutrino oscillation data, and can befurther tested by measuring the branching ratios of charged scalars$\eta_{1,2}^\pm$.

Predictive Scotogenic Model with Flavor Dependent Symmetry