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We examine a model of biological evolution of Eigen's quasispecies in a holeyfitness landscape, where the fitness of a site is either 0 (lethal site) or auniform positive constant (viable site). So, the evolution dynamics isdetermined by the topology of the genome space. It is modeled by the randomBethe lattice. We use the effective medium and single-defect approximations tofind the criteria, under which the localized quasispecies cloud is created. Wefind that shorter genomes, which are more robust to random mutations thanaverage, represent a selective advantage which we call ``topological''. A wayof assessing empirically the relative importance of reproductive success andtopological advantage is suggested.Comment: 6 pages, 5 figures, svjour class, accepted in EPJ

Selective advantage of topological disorder in biological evolution