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This study compared the effects of the most frequently employed protocols of flywheel (FW) versus weight-stack (WS) resistance exercise (RE) on regional and muscle-specific adaptations of the knee extensors. Sixteen men ( n = 8) and women ( n = 8) performed 8 weeks (2-3 days/week) of knee extension RE employing FW technology on 1 leg (4 × 7 repetitions), while the contralateral leg performed regular WS training (4 × 8-12 repetitions). Maximal strength (1-repetition maximum (1RM) in WS) and peak FW power were determined before and after training for both legs. Partial muscle volume of vastus lateralis (VL), vastus medialis (VM), vastus intermedius (VI), and rectus femoris (RF) were measured using magnetic resonance imaging. Additionally, quadriceps cross-sectional area was assessed at a proximal and a distal site. There were no differences ( P &gt; 0.05) between FW versus WS in muscle hypertrophy of the quadriceps femoris (8% vs. 9%), VL (10% vs. 11%), VM (6% vs. 8%), VI (5% vs. 5%), or RF (17% vs. 17%). Muscle hypertrophy tended ( P = 0.09) to be greater at the distal compared with the proximal site, but there was no interaction with exercise method. Increases in 1RM and FW peak power were similar across legs, yet the increase in 1RM was greater in men (31%) than in women (20%). These findings suggest that FW and WS training induces comparable muscle-specific hypertrophy of the knee extensors. Given that these robust muscular adaptations were brought about with markedly fewer repetitions in the FW compared with WS, it seems FW training can be recommended as a particularly time-efficient exercise paradigm.

Regional and muscle-specific adaptations in knee extensor hypertrophy using flywheel versus conventional weight-stack resistance exercise