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[Received for publication March Ist, I94I.] IN a communication (i) addressed to the Medical Society for the Study of Venereal Diseases by one of us (Simpson) in I936, an appraisal was made of the rdle of artificial fever therapy $ in the management of gonococcic infections. The purpose of the present report is to record the development of new technics for the eradication of gonococcic infections which are refractory to modern chemotherapeutic methods. The widespread aeceptance of sulfonamide compounds as effective agents in the treatment of gonococcic infections has modified the value of all pre-existing types of therapy. The rapidity with which most cases yield to intelligent and controlled administration of these compounds has obviated the necessity for the use of accessory therapeutic agents in such cases. As Harkness (2) has stated so aptly, modern chemotherapy is more of a specific for gonorrhea than are salvarsan and its derivatives for syphilis. The brilliance of such results has been dimmed somewhat by the development of several circumstances which will prevent the ultimate

The Eradication of Refractory Gonococcic Infections by Combined Artificial Fever-Chemo-Therapy