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Mdm2 is a natural inhibitor of p53 function and its overexpression impairs p53 transcriptional activity. T--&gt;G single-nucleotide polymorphism at position 309 (SNP309) of mdm2 induces overexpression of mdm2, but inhibits p53.

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells