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Colorectal adenomatous polyposis is associated with a high risk of colorectal cancer (CRC) and is frequently caused by germline mutations in APC or MUTYH. However, in about 20-30% of patients no underlying gene defect can be identified. In this study, we tested if recently identified CRC risk variants play a role in patients with &gt;10 adenomas.

Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis