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The results of a survey published by McDonald (1961) suggest that children born to women with pulmonary tuberculosis may show an excess of serious congenital malformations. Among a random sample of 3,295 pregnant women who were interviewed at their first antenatal visit and followed up to ascertain the outcome of their pregnancies, 61 gave a history of pulmonary tuberculosis and four of the children born to them were subsequently found to have major congenital defects (two were anencephalic, one had absent kidneys, and one a cardiac defect). Although the thalidomide disaster has underlined the need for the utmost caution when prescribing drugs for women who are or may be in the early months of pregnancy, no attempt appears to have been made to confirm or refute this observation, with its implication that one of the drugs currently used in the treatment of tuberculosis may be teratogenic. There is an additional reason for concern in that laboratory experiments suggest that streptomycin is teratogenic for rats (Filippi and Mela, 1958). The outcome of 253 pregnancies in women known to have been under supervision or treatment for pulmonary tuberculosis during pregnancy is reported below.

Congenital Defects among Children Born to Women under Supervision or Treatment for Pulmonary Tuberculosis