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The treatment of refractory cardiac pain and cardiac failure by radio-iodine has been in use for over 15 years (Blumgart, Freedberg, and Kurland, 1950, 1957; Jaffe et al., 1955; Chapman, 1958; Eliasch et al., 1959; Strong and Turner, 1962). The method has also been used to prevent the paroxysms of tachycardia and arrhythmias (Corday, Gold, and Jaffe, 1958; Liljefors, Einhorn, and Eliasch, 1966). The enthusiasm for this method has varied with the progress in pharmacotherapy and cardiac surgery. There are still, however, a number of cardiovascular conditions where no effective therapy is available. Congenital cardiovascular diseases accompanied by severe pulmonary hypertension and arterial hypoxia are frequently not able to be corrected by operation, for several reasons e.g. some combined anomalies, too great an operative risk in relation to the expected result, or a negative attitude on the part of the patients. Many of these patients become bed-ridden invalids. As far as we know no attempts have been made to evaluate the effect of treatment by radio-iodine in this type of condition. As the oxygen requirement ofthe tissues cannot be met in these patients because of arterial oxygen desaturation and low peripheral flow (Sand0e, 1963), it is reasonable to assume that a lowering of oxygen requirements can improve the symptoms due to lack of oxygen. The purpose of the present communication is to report clinical experience of treatment with relatively high doses of radio-iodine in cyanotic patients with congenital cardiac anomalies.

Radio-iodine in treatment of congenital heart disease with severe pulmonary hypertension.