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among the most significant advances in the medical treatment of these conditions in the history of medicine. These facts must be weighed against the extremely rare instances of these relatively minor epidermal reactions. Rashes are not infrequent in hypertensive patients taking methyldopa, while 1 in 5 patients treated with the latter develop a positive Coombs test and 1 in 500 go on to develop haemolytic anaemia.5 Such features have occasioned less comment than the development of this rare and usually reversible oculocutaneous syndrome in patients on treatment with beta-blocking drugs.

Ischaemic necrosis of lesser curve after proximal gastric vagotomy.