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monitoring at short notice and to remove others from the list when their time of trial is over. Anaesthesia and Radiology.-Two of the most active fields of research into new drugs are anaesthesia and radiology. About 10,000,000 anaesthetics a year are administered in this country, and in the average 700-bed teaching hospital there will be 10,000 anaesthetics a year. There are two special features of anaesthetics and of diagnostic agents used in radiology which make them of interest to our committee. They are not usually supplied on individual prescription from the pharmacy but from stocks kept in the operating theatres and x-ray departments and would therefore bypass our new monitoring mechanism. Secondly, while anaesthetists and radiologists are on the watch for immediate or early reactions they will not normally have the opportunity to observe delayed reactions. If, therefore, there was a delayed reaction which occurred two to three months later, like homologous serum hepatitis after transfusion or aplastic anaemia after gold or chloramphenicol, it might well be missed. Records of anaesthetics and diagnostic reagents used in radiology are, of course, already kept, but anaesthetists and radiologists are now carrying out pilot studies to see whether data such as the identification of the patient, the drug used, the dose and batch number where applicable, and the occurrence of reactions can be collected in a standardized form and made easy to retrieve. Fortunately the hospitals to which new drugs in these categories have been supplied can usually be quickly pinpointed.

Heller-valve method of intravenous fluid administration in neonatal surgery.