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The need to increase food production in all parts of the world has led to the use of many potentially dangerous substances for the control of weeds and insect pests. The value of D.D.T. in the control of mosquitoes, flies, and certain insects is undisputed, and many other chlorinated hydrocarbons have found a special use in pest control. Some of these substances are extremely toxic to man. Control of weeds with sprays containing dinitro-ortho-cresol (D.N.O.C.) has increased the yield in cereal crops, but in Great Britain alone seven agricultural workers have died from D.N.O.C. poisoning in the past five years. The average period during which D.N.O.C. is used is only six weeks in each year. The organic compounds of phosphorus have been most recently introduced into the group of potent agricultural chemicals. These are effective insecticides but extremely dangerous to man unless they are handled with extraordinary care. There has been a tendency to release agricultural chemicals for use by workers of varying experience before the toxic properties have been adequately studied. We know little enough about the acute toxicity of some of these substances, and almost nothing about the long-term effects of repeated small doses.

Poisoning by Organic Phosphorus Insecticides