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IN comTnencing the following investigations, specimens of the above British Pharmacopwvia preparations were obtained from Mr. Morson, of London, so that there could be no dubiety as to their genuine character.i The following points were noted as to their physical properties. 1. Natural salicylic acid obtained from salicin by oxidation or from the oil of winter green is seen in acicular crystals having a strong resemblance to strychnine. 2. Artificial salicylic acid obtained by the combination of the elements of carbolic acid and carbonic acid, and subsequent purification, is a white satiny powder in fine silky crystals resembling quinine. Both are equally soluble in rectified spirit, 20 minima of the spirit dissolving 5 grains of each acid. Salicylate of sodium (natural) is seen in crystalline plates of a white satiny appearance. Salicylate of sodium (artificial) is seen in small crystalline plates, with a slight pink colour. Both are equally soluble in water. We elected to commence our experiments with the readily soluble salt, but we resolved to begin tentatively, and watch what might happen. Salicylate of Sodium (artificial).-On June 1st, 1889, a rabbit weighing 14 oz., strong and healthy, was subjected to the following experiments :2 Before injecting a solution of sodium-salicylate (strength 1 in 3, 2 grains in 6 minims), the temperature in the rectum was taken, and found to be 100.2° F.; after two hypodermic injections of 3 minim8, at intervals of five minutes, there was no action, but the temperature fell to 995.8. Within an interval of fifteen minutes, the 3-minim injection was repeated twice. Immediately after the last injection the rabbit became excited, and executed a backward and circular or rotatory movement, which gave place to a transient paralysis of the flexors of the hind limbs, so that in attempting a forward movement the animal dragged along on its belly. All this was of a transient character, and as the experiment was not continued further the animal made an excellent recovery, without the development of any other symptom. On June 4th the experiment was resumed on the same animal, which appeared in every way healthy. The temperature in the rectum before any injection was 101.80. At intervals of five minutes 3 minims of the solution (1 in 3) were injected hypodermically. Immediately after the fourth injection the circular or rotatory and backward movements were observed, and the same degree of paralysis of the hind limbs, namely, a paresis of the

Experimental Research as to the General Comparative Action of the Natural and Artificial Salicylic Acids, and their Salts of Sodium