English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Exfoliative syndrome (ES) was first reported in 1917 by Lindberg (1), who noted greyish flakes at the pupillary border in most of his patients with chronic glaucoma. Although this entity has been recognised for more than 78 years, the essential nature of ES is still obscure. Many investigations have been made to determine the nature of ES. Extensive electron microscopic evaluation of the exfoliative material has indicated that it consists of fibrils and filaments embedded in an amorphous substance. These fibrils possess a characteristic cross banding, which usually exhibits a periodicity of 17-56 nm (2, 3). Ultrastructurally these fibrils do not resemble interstitial collagen, and this material was not soluble in a variety of enzymes such as collagenase, trypsin, pepsin and papain. Amyloid deposits resembling exfoliative material have been found on the equatorial lens capsule and the anterior and posterior surfaces of the iris in patients with primary systemic non familial amyloidosis (4). The aqueous humour IgG of patients has been found to increase significantly with senile exfoliation, indicating that there could be an immunological participitant in the pathogenesis of the exfoliative material (5). Histopathological and histochemical examinations conducted on the conjunctiva, iris and lens tissue of 15 senile pseudo-exfoliation cases and on the trabecular tissue of 3 patients with capsular glaucoma. Demonstrated these tissues to be composed of glycoproteins and proteoaminoglycans (6). The detection of positive staining of exfoliative material (EM) and zonule with aldehyde fuchsine and chrome hemotoxylin after prior oxidation has led to the proposal that fibrils of EM are related to the microfibrillary component of elastic tissue (7). All of the studies mentioned above still do not adequate explain the true causes and the pathogenesis of EM.

Association of HLA type with pseudoexfoliation of the lens capsule