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Altered concentrations of circulating serotonin have been implicated in several pathological conditions such as fibromyalgia,1–4 rheumatoid arthritis2,4,5 and major depression.6 In fibromyalgia in particular, several investigators have reported low serum serotonin levels as compared to the general population.1,3We analysed sera from 20 patients with fibromyalgia, and compared the data with that obtained on analysis of sera from age- and gender-matched controls, including 20 patients with of rheumatoid arthritis, 20 with osteoarthritis, 20 with major depression, and 20 healthy individuals. The patients with fibromyalgia had a mean number of tender points of 16.3 and a mean duration of the disease of 9.65 years. Thirteen patients …

Serum serotonin levels are not useful in diagnosing fibromyalgia