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Rheumatoid synovial cells are resistant to apoptosis induction in vivo, whereas, fibroblast-like synovial cells in rheumatoid arthritis (RA-FLS) are vulnerable to Fas-induced apoptosis in vitro.

Anchorage on fibronectin via VLA-5 ( 5 1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis