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To study interferon gamma (IFN gamma) production and the expression of T-bet and GATA-3, the transcription factors associated with Th1 and Th2, in peripheral blood mononuclear cells (PBMC) from patients with rheumatoid arthritis before and during infliximab treatment, so as to distinguish between a disease specific and a disease activity dependent defect.

annals of the rheumatic diseases

Effect of treatment of rheumatoid arthritis with infliximab on IFN , IL4, T-bet, and GATA-3 expression: link with improvement of systemic inflammation and disease activity