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Background Over time, a patient-centered evaluation of health status has become more important for systemic sclerosis (SSc), both in research and clinical setting. Patient-reported outcomes (PROs) are being increasingly used to measure various domains of disease status relevant to patients and physicians. The EULAR Outcome Measures Library (OML) is a freely available website with structured access to a growing database of validated PROs [1], but currently there are no PROs available on SSc at the EULAR OML. Objectives To provide a comprehensive review of validated SSc-specific PROs and to critically appraise their validity. Methods A sensitive search was developed in Medline and Embase (08/2015) to identify all validation studies, cohort studies, reviews or metaanalyses in which the objective were the development or validation of PROs evaluating organ involvement, disease activity or damage in SSc. A reviewer screened title and abstracts, selected the studies, and collected data concerning validation using ad hoc forms based on the COSMIN checklist. Results From 13,140 articles captured, 74 met the predefined criteria. After excluding an instrument for the unavailability of an English version, the selected studies provided information on 6 SSc-specific PROs: the Scleroderma Assessment Questionnaire (SAQ), the scleroderma functional score (FS), the Raynaud's condition score (RCS), the Mouth Handicap in SSc (MHISS), the University of California Los Angeles-Scleroderma Clinical Trial Consortium Gastro-Intestinal tract (UCLA-SCTC-GIT 2.0), and the Skin Self-Assessment. The table summarizes the instruments and their measurement properties:Table 1 SSc-specific PROs Domains No. of items and range Measurement properties Reliability IC/TR/ME Validity Responsiveness Interpretability SAQ Functional status (vascular, respiratory, GIT and musculoskeletal apparatus) Items: 23Range: 0–3 ICC 0.79–0.95 Total score higher in pts with systemic involvement Vascular z=0.92–2.97; Respiratory z=1.34–2.52; GIT z=−3.14–4.03; Musculoskeletal status z=0.68–3.16 – FS Functional ability (upper limbs & muscle weakness) Items: 11Range: 0–33 Intra-observkw 0.19–0.6inter-observkw 0.69–0.94 HAQ-DI r=0.90Skin score r=0.11 FS correlates with HAQ-DI 0.59, & Hand HAQ-DI 0.58 – RCS Severity and impact of Raynaud's phenomenon Item: 1Range 0–10 ICC 0.70 Disease activity, Rp measures, digital ulcers, mood/tension 67% variance ES 0.6SRM 0.64 MID 14–15 points (0–100 VAS)PASS 34 points MHISS Disability involving the mouth Items: 12Range: 0–48 ICC 0.96 HAQ r=0.33, CHFS r=0.37, mouth opening r=−0.34, MACTAR r=0.11, HADd r=0.26, HADa r=0.17 – – UCLA SCTC GIT 2.0 GIT symptoms severity Items: 34Range: 0–3 Cronbach's α>0.70, constipation (α=0.67)ICC 0.71 Total GIT score r=0.60; Upper GIT r=0.52; Lower GIT r=0.60 rho 0.05–0.48 MID/improvement: 0.07–0.36;MID/worsening: 0.06 −0.21;Floor: noneCeiling: 4% Skin self-assessment Skin thickening Items: 17Range: 0–51 ICC 0.5–0.61 Skin score r=0.435 No changes 1 yr follow-up – dcSScFloor <15%Ceiling <15%– lcSScFloor >15%Ceiling n.a. Conclusions Six SSc-specific PROs have a minimum validation and will be included in the EULAR OML. In general, the level of validation attained could be improved. Further development in the area of disease-specific PROs in SSc is warranted. References Castrejόn I, Gossec L, Carmona L. Ann Rheum Dis. 2015;74(2):475–6 Disclosure of Interest None declared

annals of the rheumatic diseases

SAT0583 A Systematic Review of Systemic Sclerosis Instruments for The Eular Outcome Measures Library: An Evolutionary Database of Validated Patient-Reported Instruments