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Acupuncture has been recommended as an alternative therapy for migraine. Emerging evidence suggests that the 5-HT 7 receptor (5-HT 7 R) plays a significant facilitatory role in descending modulation in migraine pathophysiology, and that activation of 5-HT 7 R in the descending pathway is involved in migraine central sensitisation.

Electroacupuncture exerts an anti-migraine effect via modulation of the 5-HT7 receptor in the conscious rat