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552 MOLECULAR MECHANISMS OF EVOLUTION   553 INSUFFICIENCY OF THE CLASSICAL MECHANISM(S)   553 Two Types of Molecular Evolution  553 Role of Mutation  554 MUTATION: A REEXAMINATION   555 STREPTOMYCIN RESISTANCE: A COMPARISON OF TWO ADAPTIVE MODES 556 TERMINOLOGY OF ECEs   557 ECOLOGY OF ECEs 558 HOST RANGES OF ECEs IN NATURAL ECOSYSTEMS   560 GENES CARRIED BY ECEs   561 GENETIC "COMPLEXITY" OF A PROKARYOTIC SPECIES   563 GENETIC PROCESSES MEDIATED BY ECEs   567 Dissemination of Existing Genes   567 cell-to-ECE-to-cell gene transfer  567 phage conversion 567 ECE-to-cell-to-ECE gene transfer   568 Genome Sizing  568 Controlled Randomization of Genomes  568 IS elements and phage Mu   568 permuted phage genomes  569 Natural Genetic Engineering   569 processes of polynucleotide exchange involving resident homology   569 polynucleotide exchange involving nonresident homology   571 evolution of R factors in bacteria    572 significance of sequence duplication in natural genetic engineering   572 universality and frequency of natural genetic engineering   574 Miscellaneous  575 OTHER EVIDENCE FOR POSSIBLE PROCESSES OF ECE-MEDIATED POLYNUCLEOTIDE EXCHANGE   575 Dispersed State of Specific (Plant) Proteins   575 "Simultaneous" Appearance of Similar Genes in Unrelated Organisms   575 PROCESSES OF POLYNUCLEOTIDE EXCHANGE AMONG EUKARYOTES ... 576 POSSIBLE INVOLVEMENT OF ECEs (RNA TUMOR VIRUSES) IN EMBRYOGENESIS  576 RNA TUMOR VIRUSES IN INTERSPECIFIC GENE TRANSFER   577 RNA TUMOR VIRUSES AND REGULATORY PROCESSES IN HIGHER ORGANISMS  578 EPIGENETIC ELEMENTS IN ANIMALS AND IN PLANTS   578 POSSIBLE CANDIDATES FOR EPIGENETIC AGENTS IN PLANTS   579 Viroids 579 Control Elements  579 Geometrical Plant Viruses   579 AN INTEGRATED THEORY OF EVOLUTION  580 LITERATURE CITED 582

Extrachromosomal elements as possible agents of adaptation and development.