Open AccessThe Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism
Author(s) -
Bjarne HoveJensen,
Ditlev E. Brodersen,
M. Cemre Manav
Publication year - 2019
Publication title -
microbiology and molecular biology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.358
H-Index - 247
eISSN - 1098-5557
pISSN - 1092-2172
DOI - 10.1128/mmbr.00040-18
Subject(s) - biology , archaea , pentose phosphate pathway , metabolism , biochemistry , ribonucleotide , crenarchaeota , enzyme , catabolism , euryarchaeota , metabolic pathway , nucleotide , gene , glycolysis
Ribosyl 1,5-bisphosphate (PRibP) was discovered 65 years ago and was believed to be an important intermediate in ribonucleotide metabolism, a role immediately taken over by its “big brother” phosphoribosyldiphosphate. Only recently has PRibP come back into focus as an important player in the metabolism of ribonucleotides with the discovery of the pentose bisphosphate pathway that comprises, among others, the intermediates PRibP and ribulose 1,5-bisphosphate (cf.
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