Open AccessThe Epigenetic Pathways to Ribosomal DNA Silencing
Author(s) -
Rakesh Srivastava,
Rashmi Srivastava,
S. Ahn
Publication year - 2016
Publication title -
microbiology and molecular biology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.358
H-Index - 247
eISSN - 1098-5557
pISSN - 1092-2172
DOI - 10.1128/mmbr.00005-16
Subject(s) - biology , heterochromatin , epigenetics , chromatin , genetics , nucleolus , histone , ribosomal dna , gene silencing , dna methylation , microbiology and biotechnology , dna , gene , gene expression , cytoplasm , phylogenetics
SUMMARY Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing inSaccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom