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Pho7 is theSchizosaccharomyces pombe fission yeast Zn2 Cys6 transcriptional factor that drives a response to phosphate starvation in which phosphate acquisition genes are upregulated. Here we report a crystal structure at 1.6-Å resolution of the Pho7 DNA-binding domain (DBD) bound at its target site 2 in thepho1 promoter (5′-TCGGAAATT).

molecular and cellular biology

Structure of Fission Yeast Transcription Factor Pho7 Bound to <i>pho1</i> Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis

Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis