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Lipsitch and Inglesby recently estimated the potential public health risks associated with research on influenza virus transmission via respiratory droplets or aerosols between ferrets, leading them to conclude that such research is too risky to be conducted (1). The authors of that and other publications (2‐4) estimatedtheprobabilityoflaboratory-acquiredinfections(LAIs) and onward transmission of the viruses under investigation, as well as the potential consequence to public health if such events were to occur. Given the weight assigned to these risk estimates, it is important that potential pitfalls in the underlying assumptions in these analyses be rigorously scrutinized. Importantly, the publishedestimateswerebasedonhistoricaldataanddidnottakeinto accountthenumerousriskreductionmeasuresthatareinplacein thelaboratorieswheretheresearchisconducted.Here,Iprovidea critical appraisal of the published work, discussing, challenging, and modifying the estimates based on the specific conditions under which the work is performed and the properties of the viruses under investigation. By doing so, the outcome of the risk assessmentchangesfromseriousriskstonegligiblerisksforhumansand the environment. As a consequence, a more balanced debate about the research on influenza virus transmission via respiratory droplets or aerosols between ferrets is warranted, in particular giventhesubstantialpublichealthbenefitsassignedtothistypeof research (5, 6). PROBABILITY OF LABORATORY-ACQUIRED INFECTIONS

Studies on Influenza Virus Transmission between Ferrets: the Public Health Risks Revisited