English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Almeida et al. (1) have interrogated the genomes of two Pneumocystis species, Pneumocystis jirovecii and its sister Pneumocystis carinii, for genes known to be involved in sexual reproductioninthewidelystudiedfissionyeastSchizosaccharomycespombe, with the hope that defining genetic pathways governing sexual reproduction in Pneumocystis will inform disease prevention strategies. Pneumocystis spp. cause host-specific lung infections in mammals, and sexual reproductive propagules appear to be the infectious stage of the life cycle (2). P. jirovecii, a genetically intractable obligate humanpathogen,causespneumoniainimmunosuppressedindividuals, with an estimated 400,000 life-threatening infections reported annually worldwide and a mortality rate of up to 80% (3). P. carinii inhabits the lungs of rats (4). P.cariniiandrelativeswerelongthoughttobeprotozoanparasites until molecular phylogenetic analysis (1988) clearly placed them within the ascomycetes (5, 6), together with baker’s yeast (Saccharomyces cerevisiae), the human pathogen Candida albicans (in the subphylumSaccharomycotina),thehumanpathogenCoccidioidesimmitis,priceyEuropeantruffles(Tuberspp.)andmorels(Morchellaspp.), andfamiliarcontemporarygeneticmodels,suchasthesaprobesNeurospora spp. and the destructive cereal pathogens Cochliobolus heterostrophus and Fusarium graminearum (all Pezizomycotina). Although in the same phylum, Pneumocystis is only distantly related to these other fungi. In fact, it is associated with a diverse group of ancient lineages at the base of the ascomycete phylogenetic tree collectively known as the Taphrinomycotina (7, 8). The Taphrinomycotina include, in addition to the Pneumocystis mammalian pathogens, Taphrinadeformans,adimorphicplantpathogenthatcausesleafcurl diseaseofpeach,andS.pombe,usedinthefermentationofmilletbeer

mbio

Pondering Mating: Pneumocystis jirovecii, the Human Lung Pathogen, Selfs without Mating Type Switching, in Contrast to Its Close Relative Schizosaccharomyces pombe