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CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+ CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients, regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment.

Modulation of the CD8+-T-Cell Response by CD4+CD25+Regulatory T Cells in Patients with Hepatitis B Virus Infection

Modulation of the CD8⁺-T-Cell Response by CD4⁺CD25⁺Regulatory T Cells in Patients with Hepatitis B Virus Infection