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The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in &gt;77% of the tumors tested may complement apoptotic effects of c-myc overexpression.

Ror γ ( Rorc ) Is a Common Integration Site in Type B Leukemogenic Virus-Induced T-Cell Lymphomas