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We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8+ T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.

Influenza Virus-Infected Epithelial Cells Present Viral Antigens to Antigen-Specific CD8+Cytotoxic T Lymphocytes

Influenza Virus-Infected Epithelial Cells Present Viral Antigens to Antigen-Specific CD8⁺Cytotoxic T Lymphocytes