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Human T-cell leukemia virus type 1 (HTLV-1) encodes a 40-kDa protein, Tax, that is a transcriptional activator of the viral long terminal repeat (reviewed in references 1 and 15). Tax has also been implicated in HTLV-1-mediated transformation of cells (2, 3, 14, 16) and in the pleiotropic activation of many cellular genes (reviewed in references 1 and 15). The study of Tax biology has been greatly aided by a series of transformed human T cells generated by investigators in Japan (10, 11, 18). Some of these cells, including the MT2 and MT4 cell lines, have been very important tissue culture tools for syncytium-forming assays of human immunodeficiency virus type 1 (HIV-1) infections (8). Recently, many reports in the literature describing MT4 cells

journal of virology

Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT4 cells: recall of MT4 cells distributed by the NIH AIDS Research and Reference Reagent Program